How can a bean stalk tell us so much about human tissue engineering? It was for this reason that the research was started, taking an alternative path beyond DNA, and to prove it, an independent researcher published a study on, when studying iPSCs and other pluripotent plant cells, he decided to cut a bean stem completely from its roots. down to the leaves. , using a tissue cutter, shortly after photocopying the cut parts to digitally reassemble and map the internal microfluidics as a template to apply to artificial tissues. The study, called “Biomimetic and Functional Artificial Tissues: Mastering Irrigation, Nutrition, Microfluidics, and Nerve Networks to Keep Cells Alive,” outlines research on the life support of nerve cells that make up artificial tissues and organs.
Through a simple bean stem, the essence of life in its heart can be studied, providing information relevant to modern medicine and even for a possible understanding of the possibility of artificial life.
The objective of this research is the collaborative work focused on the nutrition of cells in artificial tissues, in the long work of mapping the tissues and standardizing the parts, in addition to identifying the elements of the tissues and processes with a code, for each circulatory system. and nervous. The study also shows the potential that new sciences and technologies confer on the feasibility of new studies towards artificial life, which is related to greater precision in understanding everything at the nanotopographic level, including biological tissue processes. Among the themes and ideas involved in the study, in addition to the future perspectives of this research, they contemplate:
• Cataloging of microfluidic vessels and parts and data on minimal processes to keep cells alive in tissues.
• Map and codify each circulation microchannel with a code identification number linked to a data sheet.
• Generate accurate data and information to feed new production machines for artificial human tissue.
• Generate cataloged information on biological spare parts with technical sheets with complete specifications and characterizations.
• Use traditional engineering techniques for complex machines and integrated circuit architecture for microfluidic networks in human tissues.
The future intention is to map all the microfluidic and bioelectric flora of human tissues and add an identification number to each irrigation circuit as spare parts, similar to the engineering that is done in integrated circuit architecture or in mechanics. Each circulation or communication flow line identified by calling up its data sheet with all the description, technical specification and characterization to map the cellular structures in the artificial tissues, their connections, work and process they perform to stay alive. With this we will have a better understanding of the connections, receptors and their terminations of nutrition, communication and fluid transport in a detailed nanotopography.
The idea is to map the nanotopography to the surface of biological tissues at the level of cellular structure, including its connections, matrix of fluid and nerve networks. Generating biological spare parts for use in artificial organs is a trend that is based on nanotechnology, in particular nanotopography that will broaden our vision and reach the connections and supports to maintain living tissue cells, putting a clearer focus on the details of each cell
Nanotechnology and the techniques used in traditional engineering to map the components of the human body and document the parts with an identification number to call a data sheet present enormous potential for bringing together and presenting the understanding of various specialties in a single descriptive manual. . Technique similar to that used in mechanical engineering used in the aeronautical, helicopter, vehicle and complex machinery industries to have a history, control and knowledge of all the parts that make up the whole.
The main difficulty is not in the generation of new tissues, with techniques, for example, using iPSC-induced pluripotent stem cells, but in the organization and functionalization of the tissues. When repairing two living cells of a tissue, the problem is to reconnect them, in a perfect regeneration, keeping intact the network of nutrition, electrical and structural communication, as well as making this connection recognized by the organism. At this frontier of science and technology we can clearly see the differences in the practical applications of biosciences and the limited scope of the new sciences.
However, nanotopography and engineering techniques alone may not be sufficient for an entirely new tissue mapping technology, due to the complexity involved. The difference that surrounds nanotechnology and bioscience is defined not only by measurements, but also by effects, events, methods and processes.
Nanotechnology works in the range of 1-100nm, biology and biosciences go far beyond the dimensional, going from μm, nm, particle fragments around angstroms and moles. In the case of biosciences, this anthropometry of biological components does not have a standard, but we have some known approximations, biomolecules are between 2-16nm, human cells are between 25-100μm, in addition to measurements of some viruses near 150nm , the parts of the body are very varied. In this new biological anthropometry involving micro/nanoparticles, necessary parts of tissues and parasites must be considered. In general, in addition to the measures, the whole set is needed, as in process engineering, it is the precise knowledge and uses, effects, events, processes and energies involved. So simple but profound investigation as there are many cases in India especially that are exemplary and that are true seeds of great achievements, origin of great innovations that began in garages, and with the accumulation of knowledge in innovation comes the breakthrough, and the new technologies take shape.
As presented in the recently published study titled “Biomimetic and Functional Artificial Tissues: Mastering Irrigation, Nutrition, Microfluidics, and Neural Networks to Keep Cells Alive.” There are prospects for the future with a precise code for the identification of biological circuits in all fluid and nutrition circulation channels, more precise studies and even standardizations will be feasible. With these studies, the feasibility of artificial organs will become more and more precise, and even new organ formats may become common, as has already been done in spare parts for machines. As well as the identification of damaged tissues that require regeneration with an understanding and number in each termination, this preliminary study brings more technique as standardization of engineering for this science.